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Approximately 66 million adults in Europe currently live with diabetes, representing a substantial patient population for GLP-1 therapies

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Although this increases cytosolic gluconeogenesis, it is coupled with a crucial secondary effect: calcium transfer to mitochondria activates key tricarboxylic acid (TCA) cycle dehydrogenases, boosting mitochondrial energy expenditure and reducing ectopic lipid accumulation [50]

This is the not-so-secret secret, Collingwood says

Consistent weekly dosing at roughly the same time each week produces the best results

Given the global increase in the use of GLP-1 RAs and the growing number of patients at risk, further investigation into their neurological safety profile is warranted